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KMID : 0624620210540110575
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BMB Reports
2021 Volume.54 No. 11 p.575 ~ p.580
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Effects of cisplatin on mitochondrial function and autophagy-related proteins in skeletal muscle of rats
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Seo Dae-Yun
Bae Jun-Hyun
Zhang Didi
Song Wook
Kwak Hyo-Bum
Heo Jun-Won
Jung Su-Jeen
Yun Hyeong-Rok
Kim Tae-Nyun
Lee Sang-Ho
Kim Amy Hye-In
Jeong Dae-Hoon
Kim Hyoung-Kyu
Han Jin
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Abstract
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Cisplatin is widely known as an anti-cancer drug. However, the effects of cisplatin on mitochondrial function and autophagyrelated proteins levels in the skeletal muscle are unclear. The purpose of this study was to investigate the effect of different doses of cisplatin on mitochondrial function and autophagy-related protein levels in the skeletal muscle of rats. Eight-weekold male Wistar rats (n = 24) were assigned to one of three groups; the first group was administered a saline placebo (CON, n = 10), and the second and third groups were given 0.1 mg/kg body weight (BW) (n = 6), and 0.5 mg/kg BW (n = 8) of cisplatin, respectively. The group that had been administered 0.5 mg cisplatin exhibited a reduced BW, skeletal muscle tissue weight, and mitochondrial function and upregulated levels of autophagy-related proteins, including LC3II, Beclin 1, and BNIP3. Moreover, this group had a high LC3 II/I ratio in the skeletal muscle; i.e., the administration of a high dose of cisplatin decreased the muscle mass and mitochondrial function and increased the levels of autophagy-related proteins. These results, thus, suggest that reducing mitochondrial dysfunction and autophagy pathways may be important for preventing skeletal muscle atrophy following cisplatin administration.
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KEYWORD
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Autophagy, Cancer, Cisplatin, Mitochondrial function, Skeletal muscle
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